According to Jason Schreier of Kotaku, Bethesda will be announcing an Arkane Studios Austin-developed Prey 2 reboot at E3 next month.
“All I’ve heard is that they’re announcing it at E3! I’m not 100-percent sure, though. I do know it’s codenamed ‘Danielle’ and under development at Arkane Austin. And this is a totally new Prey 2 (it might even be called something else now), not the one we saw in 2011 from Human Head.”
Prey fan site Allen Noire is also reporting that Bethesda will make an announcement at E3 as well. Keep in mind this is still a rumor and Bethesda nor Arkane Studios have confirmed any of these reports.